Plant Transcription Factor Database
Previous version: v3.0
Arabidopsis thaliana
HD-ZIP Family
Species TF ID Description
AT3G01470.1homeobox 1
AT1G69780.1HD-ZIP family protein
AT5G65310.2homeobox protein 5
AT5G65310.1homeobox protein 5
AT2G22430.1homeobox protein 6
AT4G40060.1homeobox protein 16
AT5G15150.1homeobox 3
AT5G06710.1homeobox from Arabidopsis thaliana
AT2G46680.1homeobox 7
AT4G16780.1homeobox protein 2
AT4G36740.1homeobox protein 40
AT2G44910.1homeobox-leucine zipper protein 4
AT4G17460.1Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein
AT3G60390.1homeobox-leucine zipper protein 3
AT3G01220.1homeobox protein 20
AT2G18550.1homeobox protein 21
AT2G46680.2homeobox 7
AT4G37790.1HD-ZIP family protein
AT1G26960.1homeobox protein 23
AT2G22800.1HD-ZIP family protein
AT5G47370.1Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein
AT5G66700.1homeobox 53
AT3G61890.1homeobox 12
AT2G01430.1homeobox-leucine zipper protein 17
AT5G03790.1homeobox 51
AT1G27045.1HD-ZIP family protein
AT1G70920.1homeobox-leucine zipper protein 18
AT2G36610.1homeobox protein 22
AT5G53980.1homeobox protein 52
AT1G79840.1HD-ZIP family protein
AT1G79840.2HD-ZIP family protein
AT1G05230.3homeodomain GLABROUS 2
AT1G05230.1homeodomain GLABROUS 2
AT1G05230.2homeodomain GLABROUS 2
AT1G05230.4homeodomain GLABROUS 2
AT4G00730.2HD-ZIP family protein
AT4G00730.1HD-ZIP family protein
AT4G21750.1HD-ZIP family protein
AT4G21750.2HD-ZIP family protein
AT4G04890.1protodermal factor 2
AT4G32880.1homeobox gene 8
AT2G34710.1HD-ZIP family protein
AT3G61150.1homeodomain GLABROUS 1
AT1G30490.1HD-ZIP family protein
AT1G52150.3HD-ZIP family protein
AT1G52150.1HD-ZIP family protein
AT1G52150.2HD-ZIP family protein
AT1G73360.1homeodomain GLABROUS 11
AT2G32370.1homeodomain GLABROUS 3
AT5G52170.1homeodomain GLABROUS 7
AT5G60690.1HD-ZIP family protein
AT1G17920.1homeodomain GLABROUS 12
AT4G17710.1homeodomain GLABROUS 4
AT3G03260.1homeodomain GLABROUS 8
AT1G34650.1homeodomain GLABROUS 10
AT5G17320.1homeodomain GLABROUS 9
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401